{"id":1749,"date":"2003-10-01T01:00:00","date_gmt":"2003-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/les-tumeurs-endocrines-digestives-en-france-resultats-dun-enregistrement-prospectif-sur-13-mois-enquete-ffcd-angh-gercor\/"},"modified":"2018-10-20T18:39:30","modified_gmt":"2018-10-20T16:39:30","slug":"les-tumeurs-endocrines-digestives-en-france-resultats-dun-enregistrement-prospectif-sur-13-mois-enquete-ffcd-angh-gercor","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/les-tumeurs-endocrines-digestives-en-france-resultats-dun-enregistrement-prospectif-sur-13-mois-enquete-ffcd-angh-gercor\/","title":{"rendered":"LES TUMEURS ENDOCRINES DIGESTIVES EN FRANCE : r\u00e9sultats d\u2019un enregistrement prospectif sur 13 mois (enqu\u00eate FFCD \u2013 ANGH \u2013 GERCOR)"},"content":{"rendered":"

2003<\/strong><\/p>\n

E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3)<\/p>\n

E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3).(1)CHU Ambroise Par\u00e9 Boulogne, (2)CH Bourg-en-Bresse, (3)H\u00f4pital Edouard Herriot Lyon<\/em><\/p>\n

Gastroent\u00e9rologie <\/strong>– \u00a02003-06-16 –\u00a0CO –<\/p>\n

________________________________<\/p>\n

LES TUMEURS NEUROENDOCRINES ENFRANCE : r\u00e9sultats d\u2019un enregistrement prospectif sur 13 mois (enqu\u00eate FFCD \u2013 ANGH \u2013 GERCOR)<\/p>\n

E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3)<\/p>\n

(1) CHU Ambroise Par\u00e9 Boulogne, (2) CH Bourg-en-Bresse, (3) H\u00f4pital Edouard Herriot Lyon<\/p>\n

But de l\u2019\u00e9tude<\/p>\n

Enregistrement prospectif sur une p\u00e9riode de 13 mois des patients atteints de tumeurs neuro-endocrines \u00e0 localisation digestive afin d\u2019\u00e9tablir un descriptif de cette population dans sa pr\u00e9sentation clinique et dans ses modalit\u00e9s de prise en charge. Comparer les patients pris en charge dans les h\u00f4pitaux g\u00e9n\u00e9raux (centres ANGH) et dans les autres structures de soin<\/p>\n

But de l\u2019\u00e9tude<\/p>\n

Enregistrement prospectif sur une p\u00e9riode de 13 mois des patients atteints de tumeurs endocrines \u00e0 localisation digestive afin d\u2019\u00e9tablir un descriptif de cette population dans sa pr\u00e9sentation clinique et dans ses modalit\u00e9s de prise en charge. Comparer les patients pris en charge dans les h\u00f4pitaux g\u00e9n\u00e9raux (centres ANGH) et dans les autres structures de soin<\/p>\n

Malades et m\u00e9thodes<\/p>\n

L\u2019enregistrement prospectif des cas incidents et pr\u00e9valents s\u2019est d\u00e9roul\u00e9 du 01\/08\/01 au 01\/09\/02. Les variables recueillies ont \u00e9t\u00e9 analys\u00e9es globalement puis par sous-groupe (centres ANGH \/ autres centres).<\/p>\n

R\u00e9sultats<\/p>\n

668 patients (H\/F : 1,04), d\u2019\u00e2ge m\u00e9dian 56 ans (extr\u00eames 12-89 ans) ont \u00e9t\u00e9 collig\u00e9s. Sept centres universitaires ont inclus au moins dix patients et repr\u00e9sentaient 62% du recrutement. 39 centres ANGH ont inclus 97 patients (de 1 \u00e0 9) soit 14,5%. Aucun des 14 patients porteur d\u2019une N\u00e9oplasie Endocrinienne Multiple n\u2019a \u00e9t\u00e9 diagnostiqu\u00e9 dans les centres ANGH. La prise en charge initiale \u00e9tait plus souvent r\u00e9alis\u00e9e dans les centres ANGH (41%). Il n\u2019y avait pas de diff\u00e9rence inter-centre pour les donn\u00e9es cliniques, morphologiques ou biologiques et les r\u00e9sultats portent sur l\u2019ensemble des patients.
\nLes sites primitifs \u00e9taient : intestin gr\u00eale (288), pancr\u00e9as (211), inconnu (77), estomac (33), bronches (24), appendice (20), rectum (12). Des m\u00e9tastases \u00e9taient pr\u00e9sentes dans pr\u00e8s de 75% des cas (pancr\u00e9as : 72%, gr\u00eale : 77%). Dans 61% des cas elles \u00e9taient h\u00e9patiques. Ces m\u00e9tastases \u00e9taient synchrones dans 41% des tumeurs pancr\u00e9atiques et dans 46% des tumeur du gr\u00eale. 42% des patients avaient un syndrome s\u00e9cr\u00e9toire (gr\u00eale : 58%, pancr\u00e9as : 29%). Il s\u2019agissait d\u2019un syndrome carcino\u00efde dans pr\u00e8s de 82% des tumeurs du gr\u00eale et dans 20% des tumeurs pancr\u00e9atiques. Histologiquement 81% des tumeurs \u00e9taient bien diff\u00e9renci\u00e9es, 9,1% moyennement diff\u00e9renci\u00e9es et 9,4% peu diff\u00e9renci\u00e9es. Les examens morphologiques r\u00e9alis\u00e9s \u00e9taient : \u00e9chographie abdominale (85%), TDM abdominale (79%), TDM thoracique (65%), Octr\u00e9oscan (55%), \u00e9choendoscopie (34%), ent\u00e9roscanner (32%), transit du gr\u00eale (6%). Initialement les patients ont \u00e9t\u00e9 trait\u00e9s par chirurgie (60%), chimioth\u00e9rapie (20%) ou simplement surveill\u00e9s (20%). Au cours du suivi 39% des patients ont re\u00e7u une chimioth\u00e9rapie, 26% de l\u2019interf\u00e9ron, 14% une embolisation ou une chimioembolisation, 25% une chirurgie des m\u00e9tastases<\/p>\n

Conclusion<\/p>\n

En d\u00e9pit de la r\u00e9putation de raret\u00e9 de cette pathologie, un nombre \u00e9lev\u00e9 de tumeurs endocrines digestives a \u00e9t\u00e9 enregistr\u00e9. Le nombre \u00e9lev\u00e9 de participants souligne l\u2019int\u00e9r\u00eat des cliniciens pour cette pathologie et confirme les capacit\u00e9s de mobilisation des membres de l\u2019ANGH. Ces donn\u00e9es montrent qu\u2019\u00e0 cot\u00e9 des tumeurs de l\u2019appendice, la pr\u00e9valence des tumeurs endocrines digestives \u00e9volu\u00e9es justifie la r\u00e9alisation d\u2019essais cliniques multicentriques et peut-\u00eatre la poursuite de l\u2019enregistrement.<\/p>\n","protected":false},"excerpt":{"rendered":"

2003 E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3) E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3).(1)CHU Ambroise Par\u00e9 Boulogne, (2)CH Bourg-en-Bresse, (3)H\u00f4pital Edouard Herriot Lyon Gastroent\u00e9rologie – \u00a02003-06-16 –\u00a0CO – ________________________________ LES TUMEURS NEUROENDOCRINES ENFRANCE : r\u00e9sultats d\u2019un enregistrement prospectif sur 13 mois (enqu\u00eate FFCD \u2013 ANGH \u2013 GERCOR) E. Mitry(1), D.Pillon(2), C.Lombard-Bohas(3) (1) CHU Ambroise Par\u00e9 Boulogne, (2) CH Bourg-en-Bresse, (3) […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[14],"class_list":["post-1749","post","type-post","status-publish","format-standard","hentry","category-gastroenterologie","tag-14"],"yoast_head":"\nLES TUMEURS ENDOCRINES DIGESTIVES EN FRANCE : r\u00e9sultats d\u2019un enregistrement prospectif sur 13 mois (enqu\u00eate FFCD \u2013 ANGH \u2013 GERCOR) - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/les-tumeurs-endocrines-digestives-en-france-resultats-dun-enregistrement-prospectif-sur-13-mois-enquete-ffcd-angh-gercor\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LES TUMEURS ENDOCRINES DIGESTIVES EN FRANCE : r\u00e9sultats d\u2019un enregistrement prospectif sur 13 mois (enqu\u00eate FFCD \u2013 ANGH \u2013 GERCOR) - 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