{"id":1762,"date":"2003-10-01T01:00:00","date_gmt":"2003-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/utilisation-de-linfliximab-dans-la-maladie-de-crohn-etude-multicentrique-angh\/"},"modified":"2018-10-20T18:39:30","modified_gmt":"2018-10-20T16:39:30","slug":"utilisation-de-linfliximab-dans-la-maladie-de-crohn-etude-multicentrique-angh","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/utilisation-de-linfliximab-dans-la-maladie-de-crohn-etude-multicentrique-angh\/","title":{"rendered":"UTILISATION DE L’INFLIXIMAB DANS LA MALADIE DE CROHN: \u00e9TUDE MULTICENTRIQUE ANGH"},"content":{"rendered":"

2003<\/strong><\/p>\n

S. RATEL SABY, H. HAGEGE, T. PAUPARD, P. COUTAREL, B. DENIS, JL GERBAL, S. NAHON, O. NOUEL, A. PARIENTE, M. CHOUSTERMAN et LE GROUPE INFLIXIMAB DE L\u2019ANGH<\/em><\/p>\n

Gastroent\u00e9rologie <\/strong>– \u00a02000-03-09 –\u00a0CO –<\/p>\n

________________________________<\/p>\n

L’Infliximab est un traitement efficace pour certaines formes de maladie de Crohn (MC), qui est disponible en France depuis 1999. Ce m\u00e9dicament on\u00e9reux, de manipulation d\u00e9licate, n\u2019\u00e9tait utilis\u00e9 initialement que dans les centres sp\u00e9cialis\u00e9s, mais il est actuellement prescrit plus largement. Nous rapportons l’exp\u00e9rience de l’utilisation de l’Infliximab chez 46 malades suivis dans 12 services de gastro-ent\u00e9rologie d\u2019h\u00f4pital g\u00e9n\u00e9ral, membres de l’ANGH.
\nMalades et m\u00e9thodes : Quarante-six malades suivis pour MC ont \u00e9t\u00e9 trait\u00e9s par Infliximab. Il s’agissait de 29 femmes et 17 hommes d’\u00e2ge moyen 35 ans (19-64). La maladie \u00e9voluait depuis 77 mois en moyenne (2-300). L’indication au traitement \u00e9tait une corticor\u00e9sistance dans 25 cas, une corticod\u00e9pendance avec intol\u00e9rance aux cortico\u00efdes dans 7 cas et une forme fistulisante de la maladie dans 14 cas. Des manifestations extra-digestives de la maladie \u00e9taient pr\u00e9sentes dans 9 cas (20%). Les malades ont re\u00e7u une \u00e0 trois perfusions d\u2019Infliximab. Ces perfusions \u00e9taient r\u00e9alis\u00e9es en h\u00f4pital de jour dans 34 cas (74%) et en hospitalisation conventionnelle dans les autres cas. Quarante malades (87%) avaient un traitement immunosuppresseur associ\u00e9 \u00e0 l’Infliximab. Ont \u00e9t\u00e9 \u00e9tudi\u00e9es: la tol\u00e9rance au traitement et son efficacit\u00e9 en terme de r\u00e9mission, de sevrage en cortico\u00efdes et de pr\u00e9vention des rechutes.
\nR\u00e9sultats : Le traitement par Infliximab a permis d’obtenir la r\u00e9mission de la pouss\u00e9e de MC chez 39 malades (85%). Le sevrage en cortico\u00efdes a \u00e9t\u00e9 obtenu dans 26 cas (57%). Une rechute \u00e9tait constat\u00e9e chez 20 malades (43%) avec un d\u00e9lai allant de 1 \u00e0 104 semaines apr\u00e8s la derni\u00e8re perfusion d\u2019Infliximab. Sept de ces malades ont alors b\u00e9n\u00e9fici\u00e9 d’un traitement d’entretien par Infliximab \u00e0 raison d\u2019une perfusion toutes les 8 semaines. La tol\u00e9rance au traitement a \u00e9t\u00e9 tout \u00e0 fait satisfaisante; un seul cas d’hypersensibilit\u00e9 a \u00e9t\u00e9 observ\u00e9 (choc anaphylactique). Aucune infection opportuniste n’est survenue durant le suivi. La qualit\u00e9 de vie des malades a \u00e9t\u00e9 consid\u00e9r\u00e9e comme am\u00e9lior\u00e9e dans 43 cas (93%). Des probl\u00e8me administratifs li\u00e9s au co\u00fbt du traitement ont \u00e9t\u00e9 rencontr\u00e9s dans 3 des 12 centres.
\nConclusions: Ce travail montre que l’Infliximab est actuellement couramment utilis\u00e9 dans les services de gastro-ent\u00e9rologie de l\u2019ANGH et permet ainsi aux malades d\u2019\u00eatre trait\u00e9s \u00e0 proximit\u00e9 de leur domicile. Ce traitement a \u00e9t\u00e9 efficace et bien tol\u00e9r\u00e9 dans 85% des cas, mais une rechute \u00e9tait observ\u00e9e dans 43% des cas, posant alors le probl\u00e8me d’un traitement d’entretien. Le co\u00fbt \u00e9lev\u00e9 de ce traitement, qui m\u00e9riterait d’\u00eatre \u00e9valu\u00e9 plus pr\u00e9cis\u00e9ment en fonction du nombre de jours d’hospitalisation et d’arr\u00eats de travail, demeure encore un frein \u00e0 une utilisation plus large, notamment dans les h\u00f4pitaux g\u00e9n\u00e9raux.<\/p>\n","protected":false},"excerpt":{"rendered":"

2003 S. RATEL SABY, H. HAGEGE, T. PAUPARD, P. COUTAREL, B. DENIS, JL GERBAL, S. NAHON, O. NOUEL, A. PARIENTE, M. CHOUSTERMAN et LE GROUPE INFLIXIMAB DE L\u2019ANGH Gastroent\u00e9rologie – \u00a02000-03-09 –\u00a0CO – ________________________________ L’Infliximab est un traitement efficace pour certaines formes de maladie de Crohn (MC), qui est disponible en France depuis 1999. Ce […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[14],"class_list":["post-1762","post","type-post","status-publish","format-standard","hentry","category-gastroenterologie","tag-14"],"yoast_head":"\nUTILISATION DE L'INFLIXIMAB DANS LA MALADIE DE CROHN: \u00e9TUDE MULTICENTRIQUE ANGH - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/utilisation-de-linfliximab-dans-la-maladie-de-crohn-etude-multicentrique-angh\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UTILISATION DE L'INFLIXIMAB DANS LA MALADIE DE CROHN: \u00e9TUDE MULTICENTRIQUE ANGH - 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