{"id":1820,"date":"2006-10-01T01:00:00","date_gmt":"2006-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/"},"modified":"2018-10-20T18:39:40","modified_gmt":"2018-10-20T16:39:40","slug":"mici-et-cancer-donnees-epidemiologiques","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/","title":{"rendered":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques"},"content":{"rendered":"

2006<\/strong><\/p>\n

Jacques BELAICHE
\nService de Gastroent\u00e9rologie CHU Sart Tilman
\n4000 Li\u00e8ge ( Belgique)<\/em><\/p>\n

Gastroent\u00e9rologie <\/strong>– \u00a02006-07-29 –\u00a0CF –<\/p>\n

________________________________<\/p>\n

Dans les pays occidentaux, la pr\u00e9valence des maladies inflammatoires chroniques de l\u2019intestin (MICI) a augment\u00e9 de fa\u00e7on significative au cours des derni\u00e8res d\u00e9cades. L\u2019am\u00e9lioration des traitements m\u00e9dicaux et chirurgicaux a permis un allongement tr\u00e8s significatif de l\u2019esp\u00e9rance de vie des malades atteints de ces affections. Toutefois, les complications \u00e0 long terme, en particulier le risque de cancer colorectal (CRC) continuent \u00e0 poser probl\u00e8me. On estime que 2% des CRC de la population en g\u00e9n\u00e9ral surviennent chez des patients porteurs de MICI (1), et inversement, la pr\u00e9valence globale du CRC sur colon de MICI est d\u2019environ 3-4% mais, en cas de pancolite, elle atteint 6%. Globalement, les patients atteints de MICI ont, par rapport \u00e0 la population g\u00e9n\u00e9rale, un risque 5 fois sup\u00e9rieur de d\u00e9velopper un CRC.
\nLe risque accru de CRC sur colite ulc\u00e9reuse (CU) est reconnu depuis longtemps, tandis que dans la maladie de Crohn (MC) il a \u00e9t\u00e9 d\u00e9montr\u00e9 beaucoup plus r\u00e9cemment. Plusieurs s\u00e9ries hospitali\u00e8res et plus r\u00e9cemment des \u00e9tudes de population ont clairement d\u00e9montr\u00e9 que le risque sur pancolite de MC est \u00e9gal \u00e0 celui de la pancolite ulc\u00e9reuse et que les facteurs de risque associ\u00e9s sont les m\u00eames.
\nLe risque de CRC est notamment li\u00e9 \u00e0 la dur\u00e9e d\u2019\u00e9volution de la maladie et \u00e0 l\u2019\u00e9tendue de l\u2019atteinte colique. Ainsi, dans les pancolites sur CU, le risque de cancer est d\u2019environ 2% apr\u00e8s 10 ans d\u2019\u00e9volution, 10% apr\u00e8s 20 ans d\u2019\u00e9volution et environ 20% apr\u00e8s 30 ans d\u2019\u00e9volution (2). Dans les atteintes limit\u00e9es au rectum le risque relatif de CRC est de 1,7 et de 2,8 en cas de colite gauche.
\nLa dur\u00e9e d\u2019\u00e9volution de la maladie joue un r\u00f4le tr\u00e8s important puisque, en de\u00e7\u00e0 de 8 \u00e0 10 ans d\u2019\u00e9volution, le risque de CRC est tr\u00e8s faible. En revanche, apr\u00e8s 10 ans d\u2019\u00e9volution, ce risque augment de 0,5% \u00e0 1% par an. L\u2019influence de la dur\u00e9e d\u2019\u00e9volution sur le risque de CRC est pond\u00e9r\u00e9e par l\u2019\u00e2ge de d\u00e9but de la maladie qui constitue un facteur de risque ind\u00e9pendant : plus la maladie d\u00e9bute \u00e0 un \u00e2ge pr\u00e9coce, plus le risque de CRC est grand.
\nUn autre facteur essentiel de CRC est l\u2019existence d\u2019une cholangite scl\u00e9rosante primitive (CSP). On estime que 5% des patients atteints de CU pr\u00e9sentent \u00e9galement une CSP et que la CSP est associ\u00e9e 9 fois sur 10 lorsque l\u2019inflammation microscopique est prise en compte \u00e0 une MICI, et plus particuli\u00e8rement \u00e0 une CU. Pour cette raison, une coloscopie avec biopsies est recommand\u00e9e m\u00eame en l\u2019absence de l\u00e9sion macroscopique d\u00e8s le diagnostic de CSP pos\u00e9. La pr\u00e9sence d\u2019une CSP augmente le risque de CRC d\u2019un facteur 5 et ce risque atteint 50% chez un patient pr\u00e9sentant une CU \u00e9voluant depuis 25 ans.
\nComme pour le CRC sporadique, les ant\u00e9c\u00e9dents familiaux de CRC augmentent le risque d\u2019un tel cancer dans les MICI (3). Dans la CU le risque relatif est de 2,5 et atteint 9,2 si le cancer chez un parent du premier degr\u00e9 est survenu avant l\u2019\u00e2ge de 50 ans aussi bien dans la CU que la MC.
\nLe r\u00f4le d\u00e9l\u00e9t\u00e8re de l\u2019inflammation chronique reste encore d\u00e9battu m\u00eame si une \u00e9tude r\u00e9cente cas-t\u00e9moin a montr\u00e9 que l\u2019existence d\u2019une inflammation histologique active constituait un facteur de risque ind\u00e9pendant de CRC dans la CU (4). Le pouvoir protecteur potentiel des d\u00e9riv\u00e9s du 5-ASA sur le risque de CRC pourrait aussi constituer un argument indirect.
\nLe r\u00f4le de l\u2019il\u00e9ite de reflux comme facteur de risque ind\u00e9pendant de CRC sur CU doit encore \u00eatre confirm\u00e9.
\nA cot\u00e9 des facteurs de risque de CRC plusieurs facteurs peuvent au contraire contribuer \u00e0 diminuer ce risque.
\nLe traitement d\u2019entretien en continu par 5 ASA dans la CU diminue de 75% le risque de CRC et de 90% lorsque la posologie est sup\u00e9rieure ou \u00e9gale \u00e0 1,2 g\/j (5,6). En cas de traitement intermittent le risque ne diminue seulement que de 50%. A cot\u00e9 du traitement, un suivi comportant plus de deux consultations de contr\u00f4le par an et une surveillance endoscopique r\u00e9guli\u00e8re ont \u00e9t\u00e9 identifi\u00e9s comme facteurs diminuant le risque de CRC. Des donn\u00e9es r\u00e9centes ont montr\u00e9 que chez des sujets atteints \u00e0 la fois de CU et de CSP, trait\u00e9s pr\u00e9ventivement par acide ursod\u00e9soxycholique, le risque de CRC ou m\u00eame de dysplasie diminuait de 74% par rapport au non trait\u00e9s (7). En d\u00e9finitive, m\u00eame si la ch\u00e9mopr\u00e9vention semble jouer un r\u00f4le b\u00e9n\u00e9fique sur le risque de survenu de CRC, elle n\u2019influence pas pour le moment les modalit\u00e9s de d\u00e9pistage et de surveillance de ces malades (8).
\nEn conclusion, le risque de CRC est nettement accru dans les MICI. Ceci est particuli\u00e8rement vrai dans des sous-groupes de patients porteurs de pancolite, pr\u00e9sentant une maladie de longue dur\u00e9e, en cas d\u2019association \u00e0 une CSP ou d\u2019ant\u00e9c\u00e9dent familial de CRC. Son diagnostic est souvent difficile et un programme de surveillance optimal reste \u00e0 d\u00e9finir.<\/p>\n

R\u00e9f\u00e9rences
\n1.Choi \u00a8PM, Zeling MP. Similarity of colorectal cancer in Crohn\u2019s disease and ulc\u00e9rative colitis: implications for carcinogenesis and prevention. Gut 1994; 35:950-4.
\n2. Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001; 48:526-35.
\n3. Askling J, Dickman PW, Karlen P, Brostrom O, Lapidus A, Lofberg R, Ekbom A. Colorectal cancer rates among first-degree relatives of patients with inflammatory bowel disease: a population-based cohort study. Lancet 2001; 357:262-6.
\n4. Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kammm MA, Williams CB, Price AB, Talbot IC, Forbes A. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004; 126:451-9.
\n5. Eaden J, Abrams K, Ekbom A, Jackson E, Mayberry J. Colorectal cancer prevention in ulcerative colitis: a case-control study. Aliment Pharmacol Ther 2000; 14:145-53.
\n6.Velayos FS, Terdiman JP, Walsh J. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systemic review and metaanalysis of observational studies. Am J Gastroenterol 2005;100:1345-1353.
\n7. Pardi DS, Loftus EV, Kremers WK, Keach J, Lindor KD. Ursodeoxycholic acis as a chemopreventive agent in patient with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003; 124:889-93.
\n8. Itzkowitz SH, Present DH. Consensus conference: colorectal cancer screening and surveillance in inflammatory bowel disease. Inflamm Bowel Dis 2005; 11:314-21.<\/p>\n","protected":false},"excerpt":{"rendered":"

2006 Jacques BELAICHE Service de Gastroent\u00e9rologie CHU Sart Tilman 4000 Li\u00e8ge ( Belgique) Gastroent\u00e9rologie – \u00a02006-07-29 –\u00a0CF – ________________________________ Dans les pays occidentaux, la pr\u00e9valence des maladies inflammatoires chroniques de l\u2019intestin (MICI) a augment\u00e9 de fa\u00e7on significative au cours des derni\u00e8res d\u00e9cades. L\u2019am\u00e9lioration des traitements m\u00e9dicaux et chirurgicaux a permis un allongement tr\u00e8s significatif de […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[17],"class_list":["post-1820","post","type-post","status-publish","format-standard","hentry","category-gastroenterologie","tag-17"],"yoast_head":"\nMICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH\" \/>\n<meta property=\"og:description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta property=\"og:url\" content=\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\" \/>\n<meta property=\"og:site_name\" content=\"Abstracts des congr\u00e8s de l'ANGH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ANGH-2136322560030484\/\" \/>\n<meta property=\"article:published_time\" content=\"2006-10-01T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-20T16:39:40+00:00\" \/>\n<meta name=\"author\" content=\"abstracts\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"abstracts\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\"},\"author\":{\"name\":\"abstracts\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1\"},\"headline\":\"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques\",\"datePublished\":\"2006-10-01T00:00:00+00:00\",\"dateModified\":\"2018-10-20T16:39:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\"},\"wordCount\":1110,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\"},\"keywords\":[\"2006\"],\"articleSection\":[\"Gastroenterologie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\",\"url\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\",\"name\":\"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH\",\"isPartOf\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#website\"},\"datePublished\":\"2006-10-01T00:00:00+00:00\",\"dateModified\":\"2018-10-20T16:39:40+00:00\",\"description\":\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\",\"breadcrumb\":{\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/angh.net\/abstracts\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/angh.net\/abstracts\/#website\",\"url\":\"https:\/\/angh.net\/abstracts\/\",\"name\":\"Abstracts des congr\u00e8s de l'ANGH\",\"description\":\"Base de donn\u00e9es des abstracts du congr\u00e8s depuis 2003\",\"publisher\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/angh.net\/abstracts\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\",\"name\":\"ANGH\",\"url\":\"https:\/\/angh.net\/abstracts\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg\",\"contentUrl\":\"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg\",\"width\":48,\"height\":18,\"caption\":\"ANGH\"},\"image\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ANGH-2136322560030484\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1\",\"name\":\"abstracts\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"caption\":\"abstracts\"},\"url\":\"https:\/\/angh.net\/abstracts\/author\/abstracts\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH","description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/","og_locale":"fr_FR","og_type":"article","og_title":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH","og_description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","og_url":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/","og_site_name":"Abstracts des congr\u00e8s de l'ANGH","article_publisher":"https:\/\/www.facebook.com\/ANGH-2136322560030484\/","article_published_time":"2006-10-01T00:00:00+00:00","article_modified_time":"2018-10-20T16:39:40+00:00","author":"abstracts","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"abstracts","Dur\u00e9e de lecture estim\u00e9e":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#article","isPartOf":{"@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/"},"author":{"name":"abstracts","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1"},"headline":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques","datePublished":"2006-10-01T00:00:00+00:00","dateModified":"2018-10-20T16:39:40+00:00","mainEntityOfPage":{"@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/"},"wordCount":1110,"commentCount":0,"publisher":{"@id":"https:\/\/angh.net\/abstracts\/#organization"},"keywords":["2006"],"articleSection":["Gastroenterologie"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/","url":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/","name":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques - Abstracts des congr\u00e8s de l'ANGH","isPartOf":{"@id":"https:\/\/angh.net\/abstracts\/#website"},"datePublished":"2006-10-01T00:00:00+00:00","dateModified":"2018-10-20T16:39:40+00:00","description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","breadcrumb":{"@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/angh.net\/abstracts\/mici-et-cancer-donnees-epidemiologiques\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/angh.net\/abstracts\/"},{"@type":"ListItem","position":2,"name":"MICI et cancer : donn\u00e9es \u00e9pid\u00e9miologiques"}]},{"@type":"WebSite","@id":"https:\/\/angh.net\/abstracts\/#website","url":"https:\/\/angh.net\/abstracts\/","name":"Abstracts des congr\u00e8s de l'ANGH","description":"Base de donn\u00e9es des abstracts du congr\u00e8s depuis 2003","publisher":{"@id":"https:\/\/angh.net\/abstracts\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/angh.net\/abstracts\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/angh.net\/abstracts\/#organization","name":"ANGH","url":"https:\/\/angh.net\/abstracts\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/","url":"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg","contentUrl":"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg","width":48,"height":18,"caption":"ANGH"},"image":{"@id":"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ANGH-2136322560030484\/"]},{"@type":"Person","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1","name":"abstracts","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","caption":"abstracts"},"url":"https:\/\/angh.net\/abstracts\/author\/abstracts\/"}]}},"_links":{"self":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts\/1820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/comments?post=1820"}],"version-history":[{"count":0,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts\/1820\/revisions"}],"wp:attachment":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/media?parent=1820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/categories?post=1820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/tags?post=1820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}