{"id":1918,"date":"2011-10-01T01:00:00","date_gmt":"2011-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/facteurs-predictifs-de-mortalite-a-1-et-6-mois-chez-des-malades-ayant-une-hepatite-alcoolique-aigue-haa-severe-traitee-par-corticoides-dans-un-service-dhepato-gastro-enterologie-de-chg\/"},"modified":"2018-10-20T18:39:58","modified_gmt":"2018-10-20T16:39:58","slug":"facteurs-predictifs-de-mortalite-a-1-et-6-mois-chez-des-malades-ayant-une-hepatite-alcoolique-aigue-haa-severe-traitee-par-corticoides-dans-un-service-dhepato-gastro-enterologie-de-chg","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/facteurs-predictifs-de-mortalite-a-1-et-6-mois-chez-des-malades-ayant-une-hepatite-alcoolique-aigue-haa-severe-traitee-par-corticoides-dans-un-service-dhepato-gastro-enterologie-de-chg\/","title":{"rendered":"Facteurs pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 et 6 mois chez des malades ayant une h\u00e9patite alcoolique aigu\u00eb (HAA) s\u00e9v\u00e8re trait\u00e9e par cortico\u00efdes dans un service d\u2019h\u00e9pato-gastro-ent\u00e9rologie de CHG."},"content":{"rendered":"

2011<\/strong><\/p>\n

Gilles Macaigne, Florence Harnois, Jean-Fran\u00e7ois Boivin, Angel Ferrarrio, Dorian Dikov, Sadek Cheiab, Georges Bonihay, Claude Chayette. Services d\u2019h\u00e9pato-gastroent\u00e9rologie, d\u2019anatomo-pathologie et de radiologie, centre hospitalier de Lagny-Marne-la-Vall\u00e9e, 77 405 Lagny-sur-Marne Cedex.<\/em><\/p>\n

H\u00e9patologie <\/strong>– \u00a02011-05-11 –\u00a0CO –<\/p>\n

________________________________<\/p>\n

Le but de ce travail a \u00e9t\u00e9 d’\u00e9valuer les crit\u00e8res clinico-biologiques pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 mois et \u00e0 6 mois dans une population de malades hospitalis\u00e9s pour h\u00e9patite alcoolique s\u00e9v\u00e8re et trait\u00e9s par prednisolone dans un service d\u2019h\u00e9pato-gastro-ent\u00e9rologie de CHG.
\nMalades et m\u00e9thodes : tous les malades hospitalis\u00e9s dans le service entre janvier 1999 et mars 2011 avec le diagnostic d\u2019HAA s\u00e9v\u00e8re (\u00e9thylisme chronique, cytolyse h\u00e9patique avec ASAT > ALAT et score de Maddrey > 32, plus ou moins confirmation histologique du diagnostic) ont \u00e9t\u00e9 inclus. Un traitement par prednisolone \u00e9tait d\u00e9but\u00e9 au cours des premiers jours d\u2019hospitalisation et poursuivi 28 jours quelque soit l\u2019\u00e9volution de la bilirubin\u00e9mie jusqu\u2019en 2008 puis stopp\u00e9 au 7\u00e8me jour en l\u2019absence de diminution de la bilirubin\u00e9mie. Les donn\u00e9es cliniques, biologiques et histologiques ont \u00e9t\u00e9 revues de fa\u00e7on r\u00e9trospective jusqu\u2019en octobre 2003 puis prospectivement jusqu\u2019en avril 2011.
\nR\u00e9sultats : 151 \u00e9pisodes d\u2019HAA s\u00e9v\u00e8re survenus chez 129 malades (37.2% de femmes ; \u00e2ge moyen 52.2 ans) hospitalis\u00e9s durant cette p\u00e9riode ont \u00e9t\u00e9 \u00e9tudi\u00e9s. Le diagnostic a \u00e9t\u00e9 confirm\u00e9 histologiquement chez 104 d\u2019entre-eux (69%). Les 2 groupes de malades n\u2019\u00e9taient pas diff\u00e9rents concernant l\u2019\u00e2ge moyen, le score de Maddrey initial, le taux de mortalit\u00e9 et les diff\u00e9rents param\u00e8tres clinico-biologiques initiaux. Les taux de mortalit\u00e9 \u00e0 1 mois et \u00e0 6 mois de l’ensemble de la cohorte \u00e9taient respectivement de 19,8% et 32.4%. Les facteurs clinico-biologiques suivants ont \u00e9t\u00e9 recueillis au d\u00e9but de la prise en charge (co-morbidit\u00e9s cardiaques, pulmonaires, r\u00e9nales, diab\u00e8te, traitement b\u00e9ta-bloquant, gradient de pression porto-cave, index de Maddrey, score MELD\/Na, score de child-pugh, infection initiale, antibioprophylaxie, h\u00e9morragie digestive, score de Lille, ASAT, GGT, leucocytes, cr\u00e9atinin\u00e9mie), \u00e0 1 mois (score MELD\/Na, score de child-pugh, cr\u00e9atinin\u00e9mie) et \u00e0 6 mois (score MELD\/Na, score de child-pugh, cr\u00e9atinin\u00e9mie, ASAT, GGT) de suivi. Les facteurs pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 mois et \u00e0 6 mois ont \u00e9t\u00e9 analys\u00e9s en analyse uni et multivari\u00e9e.
\nConclusion : Dans cette cohorte, les taux de mortalit\u00e9 \u00e0 1 mois et \u00e0 6 mois \u00e9taient respectivement de 19,8% et 32.4%. Les r\u00e9sultats complets et d\u00e9finitifs de ce travail seront communiqu\u00e9s au cours de la communication orale \u00e0 Saint Malo.<\/p>\n","protected":false},"excerpt":{"rendered":"

2011 Gilles Macaigne, Florence Harnois, Jean-Fran\u00e7ois Boivin, Angel Ferrarrio, Dorian Dikov, Sadek Cheiab, Georges Bonihay, Claude Chayette. Services d\u2019h\u00e9pato-gastroent\u00e9rologie, d\u2019anatomo-pathologie et de radiologie, centre hospitalier de Lagny-Marne-la-Vall\u00e9e, 77 405 Lagny-sur-Marne Cedex. H\u00e9patologie – \u00a02011-05-11 –\u00a0CO – ________________________________ Le but de ce travail a \u00e9t\u00e9 d’\u00e9valuer les crit\u00e8res clinico-biologiques pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 mois et […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[22],"class_list":["post-1918","post","type-post","status-publish","format-standard","hentry","category-hepatologie","tag-22"],"yoast_head":"\nFacteurs pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 et 6 mois chez des malades ayant une h\u00e9patite alcoolique aigu\u00eb (HAA) s\u00e9v\u00e8re trait\u00e9e par cortico\u00efdes dans un service d\u2019h\u00e9pato-gastro-ent\u00e9rologie de CHG. - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/facteurs-predictifs-de-mortalite-a-1-et-6-mois-chez-des-malades-ayant-une-hepatite-alcoolique-aigue-haa-severe-traitee-par-corticoides-dans-un-service-dhepato-gastro-enterologie-de-chg\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Facteurs pr\u00e9dictifs de mortalit\u00e9 \u00e0 1 et 6 mois chez des malades ayant une h\u00e9patite alcoolique aigu\u00eb (HAA) s\u00e9v\u00e8re trait\u00e9e par cortico\u00efdes dans un service d\u2019h\u00e9pato-gastro-ent\u00e9rologie de CHG. - 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