{"id":1923,"date":"2011-10-01T01:00:00","date_gmt":"2011-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/"},"modified":"2018-10-20T18:39:58","modified_gmt":"2018-10-20T16:39:58","slug":"une-elevation-bien-inquietante-de-lalpha-foetoproteine","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/","title":{"rendered":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l’alpha foetoprot\u00e9ine"},"content":{"rendered":"

2011<\/strong><\/p>\n

S\u00e9verine Hommel (1), Magali Picon (1), Fran\u00e7ois Cessot (1), Serge Erlinger(1), Didier Mathieu (1)
\n(1) Centre Hospitalier du Pays d’Aix, Service du Dr PICON, Gastroent\u00e9rologie, Avenue des Tamaris, 13090 Aix en Provence<\/em><\/p>\n

H\u00e9patologie <\/strong>– \u00a02011-05-12 –\u00a0PW –<\/p>\n

________________________________<\/p>\n

Nous rapportons le cas d’une patiente ag\u00e9e de 32 ans adress\u00e9e pour bilan d’une \u00e9l\u00e9vation isol\u00e9e de l’alpha foetoprot\u00e9ine (AFP) \u00e0 51,3 ng\/ml, d\u00e9couverte dans le cadre du bilan d’un syndrome abdominal douloureux.
\nCette patiente pr\u00e9sente comme principaux ant\u00e9c\u00e9dents: une p\u00e9ricardite aigue virale, un tabagisme actif \u00e0 5 PA et ne prend aucun traitement au long cours.
\nDevant des douleurs abdominales \u00e9voluant depuis plusieurs mois, associ\u00e9es \u00e0 des ballonnements et \u00e0 des troubles du transit \u00e0 type de constipation, un bilan biologique est prescrit par le m\u00e9decin traitant montrant l’absence de syndrome inflammatoire,un bilan h\u00e9patique et un h\u00e9mogramme normaux mais un dosage d’AFP \u00e9lev\u00e9 \u00e0 51,3 ng\/ml. L’\u00e9chographie abdominale coupl\u00e9e \u00e0 un doppler revient normale. L’interrogatoire minutieux ne retrouve aucune prise m\u00e9dicamenteuse, aucune prise de toxique ni intoxication \u00e9thylotabagique.
\nUn 2\u00b0 dosage d’AFP est effectu\u00e9, confirmant l’\u00e9l\u00e9vation \u00e0 45.9 ng\/ml. Le dosage des B\u00eata HCG ainsi que les s\u00e9rologies virales (VHA, VHE, VHB, VHC) sont n\u00e9gatives. Le scanner thoracoabdominopelvien \u00e9limine une n\u00e9oplasie profonde (cancer pancr\u00e9atique, germinal ou h\u00e9patocarcinome). L’\u00e9volution des douleurs est favorable sous traitement symptomatique (M\u00e9t\u00e9ospasmyl et Movicol, sans r\u00e9cidive \u00e0 son arr\u00eat.
\nLe diagnostic d’\u00e9l\u00e9vation h\u00e9r\u00e9ditaire de l’AFP est \u00e9voqu\u00e9 puis confirm\u00e9 par le dosage d’AFP revenat \u00e9lev\u00e9 chez le p\u00e8re de la patiente (36,3 ng\/ml), normal chez la m\u00e8re, la soeur puis l’oncle et la tante paternelle (taux normaux).
\nCe syndrome d\u00e9crit pour la permi\u00e8re fois en 1983 a une transmission avec un trait autosomique dominant. 5 cas ont \u00e9t\u00e9 rapport\u00e9s dans la litt\u00e9rature (H.Schefer et al, Annals of Oncology 9: 667-72, 1998). Il n’est retenu qu’apr\u00e8s avoir \u00e9limin\u00e9 une tumeur germinale, une grossesse, un h\u00e9patocarcinome,un cancer de l’estomac, un cancer bronchique, un cancer colorectal et un cancer pancr\u00e9atique.
\nEn cas de forte suspicion diagnostique, la confirmation repose sur l’analyse familiale des taux d’AFP.
\nIl faut savoir donc \u00e9voquer ce diagnostic mais surtout \u00eatre capable de prescrire \u00e0 bon escient un tel dosage.<\/p>\n","protected":false},"excerpt":{"rendered":"

2011 S\u00e9verine Hommel (1), Magali Picon (1), Fran\u00e7ois Cessot (1), Serge Erlinger(1), Didier Mathieu (1) (1) Centre Hospitalier du Pays d’Aix, Service du Dr PICON, Gastroent\u00e9rologie, Avenue des Tamaris, 13090 Aix en Provence H\u00e9patologie – \u00a02011-05-12 –\u00a0PW – ________________________________ Nous rapportons le cas d’une patiente ag\u00e9e de 32 ans adress\u00e9e pour bilan d’une \u00e9l\u00e9vation isol\u00e9e […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[22],"class_list":["post-1923","post","type-post","status-publish","format-standard","hentry","category-hepatologie","tag-22"],"yoast_head":"\nUne \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH\" \/>\n<meta property=\"og:description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta property=\"og:url\" content=\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\" \/>\n<meta property=\"og:site_name\" content=\"Abstracts des congr\u00e8s de l'ANGH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ANGH-2136322560030484\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-10-01T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-20T16:39:58+00:00\" \/>\n<meta name=\"author\" content=\"abstracts\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"abstracts\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\"},\"author\":{\"name\":\"abstracts\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1\"},\"headline\":\"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l’alpha foetoprot\u00e9ine\",\"datePublished\":\"2011-10-01T00:00:00+00:00\",\"dateModified\":\"2018-10-20T16:39:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\"},\"wordCount\":410,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\"},\"keywords\":[\"2011\"],\"articleSection\":[\"Hepatologie\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\",\"url\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\",\"name\":\"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH\",\"isPartOf\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#website\"},\"datePublished\":\"2011-10-01T00:00:00+00:00\",\"dateModified\":\"2018-10-20T16:39:58+00:00\",\"description\":\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\",\"breadcrumb\":{\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/angh.net\/abstracts\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l’alpha foetoprot\u00e9ine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/angh.net\/abstracts\/#website\",\"url\":\"https:\/\/angh.net\/abstracts\/\",\"name\":\"Abstracts des congr\u00e8s de l'ANGH\",\"description\":\"Base de donn\u00e9es des abstracts du congr\u00e8s depuis 2003\",\"publisher\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/angh.net\/abstracts\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/angh.net\/abstracts\/#organization\",\"name\":\"ANGH\",\"url\":\"https:\/\/angh.net\/abstracts\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg\",\"contentUrl\":\"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg\",\"width\":48,\"height\":18,\"caption\":\"ANGH\"},\"image\":{\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ANGH-2136322560030484\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1\",\"name\":\"abstracts\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g\",\"caption\":\"abstracts\"},\"url\":\"https:\/\/angh.net\/abstracts\/author\/abstracts\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH","description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/","og_locale":"fr_FR","og_type":"article","og_title":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH","og_description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","og_url":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/","og_site_name":"Abstracts des congr\u00e8s de l'ANGH","article_publisher":"https:\/\/www.facebook.com\/ANGH-2136322560030484\/","article_published_time":"2011-10-01T00:00:00+00:00","article_modified_time":"2018-10-20T16:39:58+00:00","author":"abstracts","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"abstracts","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#article","isPartOf":{"@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/"},"author":{"name":"abstracts","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1"},"headline":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l’alpha foetoprot\u00e9ine","datePublished":"2011-10-01T00:00:00+00:00","dateModified":"2018-10-20T16:39:58+00:00","mainEntityOfPage":{"@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/"},"wordCount":410,"commentCount":0,"publisher":{"@id":"https:\/\/angh.net\/abstracts\/#organization"},"keywords":["2011"],"articleSection":["Hepatologie"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/","url":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/","name":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l'alpha foetoprot\u00e9ine - Abstracts des congr\u00e8s de l'ANGH","isPartOf":{"@id":"https:\/\/angh.net\/abstracts\/#website"},"datePublished":"2011-10-01T00:00:00+00:00","dateModified":"2018-10-20T16:39:58+00:00","description":"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study","breadcrumb":{"@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/angh.net\/abstracts\/une-elevation-bien-inquietante-de-lalpha-foetoproteine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/angh.net\/abstracts\/"},{"@type":"ListItem","position":2,"name":"Une \u00e9l\u00e9vation bien inqui\u00e9tante de l’alpha foetoprot\u00e9ine"}]},{"@type":"WebSite","@id":"https:\/\/angh.net\/abstracts\/#website","url":"https:\/\/angh.net\/abstracts\/","name":"Abstracts des congr\u00e8s de l'ANGH","description":"Base de donn\u00e9es des abstracts du congr\u00e8s depuis 2003","publisher":{"@id":"https:\/\/angh.net\/abstracts\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/angh.net\/abstracts\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/angh.net\/abstracts\/#organization","name":"ANGH","url":"https:\/\/angh.net\/abstracts\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/","url":"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg","contentUrl":"https:\/\/angh.net\/abstracts\/wp-content\/uploads\/sites\/2\/2018\/10\/logo_angh_2018_-48px.jpg","width":48,"height":18,"caption":"ANGH"},"image":{"@id":"https:\/\/angh.net\/abstracts\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ANGH-2136322560030484\/"]},{"@type":"Person","@id":"https:\/\/angh.net\/abstracts\/#\/schema\/person\/f532083854369dca4b9f509cfbad90e1","name":"abstracts","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2bb25d9cedd377e33f0ebc4fb5994a2f9d3e02f897704acdcc173c15b7c75253?s=96&d=mm&r=g","caption":"abstracts"},"url":"https:\/\/angh.net\/abstracts\/author\/abstracts\/"}]}},"_links":{"self":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts\/1923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/comments?post=1923"}],"version-history":[{"count":0,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/posts\/1923\/revisions"}],"wp:attachment":[{"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/media?parent=1923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/categories?post=1923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/angh.net\/abstracts\/wp-json\/wp\/v2\/tags?post=1923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}