{"id":1974,"date":"2013-10-01T01:00:00","date_gmt":"2013-10-01T00:00:00","guid":{"rendered":"https:\/\/angh.net\/abstracts\/telaprevir-dysfonction-renale-et-anemie\/"},"modified":"2018-10-20T18:40:08","modified_gmt":"2018-10-20T16:40:08","slug":"telaprevir-dysfonction-renale-et-anemie","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/telaprevir-dysfonction-renale-et-anemie\/","title":{"rendered":"T\u00e9laprevir, dysfonction r\u00e9nale et an\u00e9mie."},"content":{"rendered":"

2013<\/strong><\/p>\n

R\u00e9my AJ(1), Nalet B(2), Henrion J(3), Lesgourgues B(4), Arotcarena R(6), Hag\u00e8ge H(5), Pariente A(6), pour un groupe d\u2019investigateurs de l\u2019 ANGH (Etude Aprovvie).
\n(1) Perpignan, (2) Mont\u00e9limar, (3) Jollimont, (4) Montfermeil, (5) Cr\u00e9teil, (6) Pau<\/em><\/p>\n

H\u00e9patologie <\/strong>– \u00a02013-05-06 –\u00a0CO –<\/p>\n

________________________________<\/p>\n

Introduction : L’addition de t\u00e9laprevir \u00e0 la bith\u00e9rapie p\u00e9gyl\u00e9e augmente la fr\u00e9quence et la s\u00e9v\u00e9rit\u00e9 de l’an\u00e9mie. Le r\u00f4le d’une dysfonction r\u00e9nale associ\u00e9e est inconnu.<\/p>\n

But de l’\u00e9tude: \u00e9valuer la fr\u00e9quence d’une dysfonction r\u00e9nale sous T et sa relation \u00e9ventuelle \u00e0 l’an\u00e9mie dans une cohorte de malades atteints d’h\u00e9patite chronique C trait\u00e9s \u00ab\u00a0dans la vraie vie\u00a0\u00bb.<\/p>\n

Malades: Parmi les malades inclus dans l’observatoire \u00ab\u00a0Aprovvie\u00a0\u00bb mis en route par l’ ANGH en octobre 2012, trait\u00e9s par t\u00e9laprevir, interf\u00e9ron pegyl\u00e9 et ribavirine, on a obtenu une mesure de l’ h\u00e9moglobin\u00e9mie et de la cr\u00e9atinin\u00e9mie \u00e0 S0,S4,S8 et S12 chez 62 d’entre eux. Il s’agissait de 40 hommes et 23 femmes, de 40 ans d’\u00e2ge m\u00e9dian (27-76), de poids m\u00e9dian 71 kg (42-105), infect\u00e9s par un virus de g\u00e9notype 1 (1a:30, 1b: 24,1 non pr\u00e9cis\u00e9 9). Quatorze \u00e9taient na\u00effs de traitement, 5 non r\u00e9pondeurs nuls, 16 non r\u00e9pondeurs partiels, 8 non r\u00e9pondeurs ind\u00e9finis, 19 rechuteurs. Trente-neuf avaient une fibrose s\u00e9v\u00e8re dont 20 une cirrhose,
\nL’ Hb m\u00e9diane basale \u00e9tait de 14,8 g\/dL, la cr\u00e9atinin\u00e9mie basale m\u00e9diane de 68 \u00b5M, la clairance estim\u00e9e de la cr\u00e9atinine CEC (MDRD) \u00e9tait de 108 mL\/mn.
\nM\u00e9thodes: Hb, cr\u00e9atinin\u00e9mie (C), et CEC ont \u00e9t\u00e9 compar\u00e9es aux valeurs basales \u00e0 S4,S8 et S12. Les coefficients de corr\u00e9lation entre les variations de la cr\u00e9atinin\u00e9mie et celles de l’ Hb ont \u00e9t\u00e9 calcul\u00e9s. Les caract\u00e9ristiques des malades d\u00e9veloppant ou non une insuffisance r\u00e9nale (CEC≤ 60 mL\/min) ont \u00e9t\u00e9 compar\u00e9es.
\nR\u00e9sultats : On observait une diminution significative de l\u2019 Hb \u00e0 S4,S8 et S12 par rapport \u00e0 S0, de S4 ainsi qu\u2019une augmentation significative de la C \u00e0 S4,S8 et S12 par rapport \u00e0 S0, la variation maximale de l\u2019 Hb \u00e9tant de -4,0\u00b11,8 g\/dL et celle de la C de +15,9 \u00b1 23 \u00b5M. Il existait une corr\u00e9lation significative entre la variation maximale de Hb et celle de C (R2=0,17,p=0,008).
\nCinq malades (8%) eurent une CEC < 60 mL\/min. Par rapport \u00e0 ceux sans insuffisance r\u00e9nale, il \u00e9taient plus \u00e2g\u00e9s, plus souvent des femmes, avec un poids et une dose de ribavirine\/kg similaire,une fibrose plus s\u00e9v\u00e8re, une tendance \u00e0 une Hb initiale et une CEC plus basses. L\u2019Hb minimale \u00e9tait beaucoup plus basse, le recours \u00e0 la transfusion (3\/5), \u00e0 l\u2019 EPO (4\/5) et la r\u00e9duction de la dose de ribavirine plus fr\u00e9quents.<\/p>\n

Conclusions : La trith\u00e9rapie avec du t\u00e9laprevir est accompagn\u00e9e d\u2019une diminution significative de la fonction r\u00e9nale qui est corr\u00e9l\u00e9e \u00e0 la s\u00e9v\u00e9rit\u00e9 de l\u2019an\u00e9mie. Une surveillance pr\u00e9coce et r\u00e9guli\u00e8re de la cr\u00e9atinin\u00e9mie est n\u00e9cessaire.<\/p>\n","protected":false},"excerpt":{"rendered":"

2013 R\u00e9my AJ(1), Nalet B(2), Henrion J(3), Lesgourgues B(4), Arotcarena R(6), Hag\u00e8ge H(5), Pariente A(6), pour un groupe d\u2019investigateurs de l\u2019 ANGH (Etude Aprovvie). (1) Perpignan, (2) Mont\u00e9limar, (3) Jollimont, (4) Montfermeil, (5) Cr\u00e9teil, (6) Pau H\u00e9patologie – \u00a02013-05-06 –\u00a0CO – ________________________________ Introduction : L’addition de t\u00e9laprevir \u00e0 la bith\u00e9rapie p\u00e9gyl\u00e9e augmente la fr\u00e9quence et […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[24],"class_list":["post-1974","post","type-post","status-publish","format-standard","hentry","category-hepatologie","tag-24"],"yoast_head":"\nT\u00e9laprevir, dysfonction r\u00e9nale et an\u00e9mie. - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/telaprevir-dysfonction-renale-et-anemie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u00e9laprevir, dysfonction r\u00e9nale et an\u00e9mie. - 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