{"id":2301,"date":"2019-12-31T19:32:10","date_gmt":"2019-12-31T18:32:10","guid":{"rendered":"https:\/\/angh.net\/abstracts\/la-pharmacocinetique-du-baclofene-nest-pas-differente-chez-les-patients-ayant-une-cirrhose\/"},"modified":"2019-12-31T19:32:10","modified_gmt":"2019-12-31T18:32:10","slug":"la-pharmacocinetique-du-baclofene-nest-pas-differente-chez-les-patients-ayant-une-cirrhose","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/la-pharmacocinetique-du-baclofene-nest-pas-differente-chez-les-patients-ayant-une-cirrhose\/","title":{"rendered":"La pharmacocin\u00e9tique du baclof\u00e8ne n\u2019est pas diff\u00e9rente chez les patients ayant une cirrhose"},"content":{"rendered":"<p><strong>2019<\/strong><\/p>\n<p><em>C. Barrault1, J-B.Trabut2, S. Alqallaf 1, F. Plait3, R. Reis3, L. Labat3, J. Barr\u00e94, L. Chevillard5, X. Decl\u00e8ves3,5<\/p>\n<p>1 \u2013 Service d\u2019h\u00e9pato-gastro-ent\u00e9rologie, CH Intercommunal, Cr\u00e9teil, France<br \/>\n2 \u2013 Service d\u2019addictologie, CHU Emile Roux, Limeil-Brevannes, France<br \/>\n3 &#8211; Biologie du m\u00e9dicament et toxicologie, Paris, France<br \/>\n4- Centre de recherche biologique \u2013 CH Intercommunal, Cr\u00e9teil, France<br \/>\n5- Inserm U1144 \u2013 Paris, France<\/em><\/p>\n<p><strong>H\u00e9patologie <\/strong>&#8211; \u00a02019-05-19 &#8211;\u00a0CO &#8211;<\/p>\n<p>________________________________<\/p>\n<p>Rationnel: L\u2019efficacit\u00e9 du baclof\u00e8ne est dose-d\u00e9pendante avec une grande variabilit\u00e9 interindividuelle. Son \u00e9limination r\u00e9nale permet son utilisation en cas de cirrhose. Nous souhaitions \u00e9valuer sa pharmacocin\u00e9tique (PK) en fonction de l\u2019existence d\u2019une cirrhose. M\u00e9thode: Un dosage plasmatique (pic et\/ou r\u00e9siduel) du baclof\u00e8ne a \u00e9t\u00e9 r\u00e9alis\u00e9 chez des patients trait\u00e9s pour m\u00e9susage d\u2019alcool. Le bilan biologique comprenait l\u2019estimation de la fonction r\u00e9nale. Le diagnostic de cirrhose \u00e9tait clinique ou bas\u00e9 sur une \u00e9lastom\u00e9trie \u2265 15 kPa. La mesure du baclof\u00e8ne plasmatique a \u00e9t\u00e9 r\u00e9alis\u00e9e par spectrom\u00e9trie. La PK a \u00e9t\u00e9 d\u00e9termin\u00e9e en utilisant l&rsquo;approche pharmacocin\u00e9tique de population. R\u00e9sultats: Parmi les 72 patients, 14 avaient une cirrhose. La posologie m\u00e9diane de baclof\u00e8ne \u00e9tait de  55 mg\/j (15 \u00e0 270). La concentration de baclof\u00e8ne \u00e9tait quantifi\u00e9e \u00e0 partir de 101 \u00e9chantillons. Sur les 72 premiers, un mod\u00e8le \u00e0 un compartiment avec absorption fixe du 1er ordre (ka = 2.23 h-1) et \u00e9limination a permis de d\u00e9terminer les valeurs moyennes pour la clairance (CL\/F) et le volume de distribution \u00e0 8.01 L\/h et 45 L. La variabilit\u00e9 inter-individuelle sur CL\/F \u00e9tait de 30%. Les marqueurs biologiques h\u00e9patiques et l\u2019\u00e9lasticit\u00e9 n&rsquo;avaient aucun impact sur la PK du baclof\u00e8ne. Seule la clairance de la cr\u00e9atinine-MDRD modifiait statistiquement la clairance du baclof\u00e8ne. Conclusion: Les r\u00e9sultats pr\u00e9liminaires de cette \u00e9tude sugg\u00e8rent que l\u2019existence d\u2019une cirrhose n\u2019a pas d\u2019impact sur la pharmacocin\u00e9tique du baclof\u00e8ne, ce qui est rassurant pour les cliniciens. Les r\u00e9sultats seront compl\u00e9t\u00e9s sur l\u2019ensemble des \u00e9chantillons pour le congr\u00e8s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2019 C. Barrault1, J-B.Trabut2, S. Alqallaf 1, F. Plait3, R. Reis3, L. Labat3, J. Barr\u00e94, L. Chevillard5, X. Decl\u00e8ves3,5 1 \u2013 Service d\u2019h\u00e9pato-gastro-ent\u00e9rologie, CH Intercommunal, Cr\u00e9teil, France 2 \u2013 Service d\u2019addictologie, CHU Emile Roux, Limeil-Brevannes, France 3 &#8211; Biologie du m\u00e9dicament et toxicologie, Paris, France 4- Centre de recherche biologique \u2013 CH Intercommunal, Cr\u00e9teil, France [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[30],"class_list":["post-2301","post","type-post","status-publish","format-standard","hentry","category-hepatologie","tag-30"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La pharmacocin\u00e9tique du baclof\u00e8ne n\u2019est pas diff\u00e9rente chez les patients ayant une cirrhose - 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