{"id":2324,"date":"2020-09-25T22:13:28","date_gmt":"2020-09-25T20:13:28","guid":{"rendered":"https:\/\/angh.net\/abstracts\/liver-tests-abnormalities-are-associated-with-a-poorer-prognosis-in-covid-19-patients-results-of-a-french-cohort\/"},"modified":"2020-09-25T22:13:28","modified_gmt":"2020-09-25T20:13:28","slug":"liver-tests-abnormalities-are-associated-with-a-poorer-prognosis-in-covid-19-patients-results-of-a-french-cohort","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/liver-tests-abnormalities-are-associated-with-a-poorer-prognosis-in-covid-19-patients-results-of-a-french-cohort\/","title":{"rendered":"LIVER TESTS ABNORMALITIES ARE ASSOCIATED WITH A POORER PROGNOSIS IN COVID-19 PATIENTS: RESULTS OF A FRENCH COHORT"},"content":{"rendered":"

2020<\/strong><\/p>\n

Sayma Chaibi (1), Weam El Hadjj (1), Yael Abitbol (1), Sarah Taieb (1), Clemence Horaist (1), Vincent Jouannaud (1), Jacques Piquet (2), Cyril Maurer (2), Pierre Lahmek (3), St\u00e9phane Nahon (1)<\/em><\/p>\n

H\u00e9patologie <\/strong>– \u00a02020-07-03 –\u00a0CO –<\/p>\n

________________________________<\/p>\n

Aim
\nTo assess the impact of liver function test (LFT) abnormalities on the prognosis of patients with coronavirus disease 2019 (COVID-19) in a French cohort of hospitalized patients.<\/p>\n

Patients and method
\nFrom March 13 to April 22, 2020, we collected on a computerized and anonymized database, medical records, laboratory data and clinical outcomes of patients hospitalized for confirmed cases of COVID-19 infection (RT\u2013PCR and\/or CT-scan). Patients were followed up until April 22 2020 or until death or discharge. We have considered for statistical analysis, LFT abnormalities with levels greater than two times the upper limit of normal. Composite endpoint included admission to ICU, mechanical ventilation, severe radiologic injury and death to define disease severity.<\/p>\n

Results
\nAmong 281 patients with COVID-19, 102 (36.3%) had abnormal LFT. Elevated levels of ALT or AST was associated with the severe composite endpoint in multivariate analysis (OR 6.20, 95% confidence interval \uf05b1.84, 20.95\uf05d, p-value 0.003)
\nConclusion
\nMost of liver injuries are mild and transient during COVID-19. LFT abnormalities are associated with a poorer prognosis and could be a relevant biomarker for early detection of severe infection.<\/p>\n","protected":false},"excerpt":{"rendered":"

2020 Sayma Chaibi (1), Weam El Hadjj (1), Yael Abitbol (1), Sarah Taieb (1), Clemence Horaist (1), Vincent Jouannaud (1), Jacques Piquet (2), Cyril Maurer (2), Pierre Lahmek (3), St\u00e9phane Nahon (1) H\u00e9patologie – \u00a02020-07-03 –\u00a0CO – ________________________________ Aim To assess the impact of liver function test (LFT) abnormalities on the prognosis of patients with […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[31],"class_list":["post-2324","post","type-post","status-publish","format-standard","hentry","category-hepatologie","tag-31"],"yoast_head":"\nLIVER TESTS ABNORMALITIES ARE ASSOCIATED WITH A POORER PROGNOSIS IN COVID-19 PATIENTS: RESULTS OF A FRENCH COHORT - Abstracts des congr\u00e8s de l'ANGH<\/title>\n<meta name=\"description\" content=\"ANGH R\u00e9sum\u00e9s congr\u00e8s H\u00e9patologie Gastroent\u00e9romogie Hepatology Gastroenterology Etudes cliniques Clinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/angh.net\/abstracts\/liver-tests-abnormalities-are-associated-with-a-poorer-prognosis-in-covid-19-patients-results-of-a-french-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LIVER TESTS ABNORMALITIES ARE ASSOCIATED WITH A POORER PROGNOSIS IN COVID-19 PATIENTS: RESULTS OF A FRENCH COHORT - 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