{"id":2680,"date":"2025-10-18T12:31:27","date_gmt":"2025-10-18T10:31:27","guid":{"rendered":"https:\/\/angh.net\/abstracts\/?p=2680"},"modified":"2025-10-18T12:31:28","modified_gmt":"2025-10-18T10:31:28","slug":"etude-du-positionnement-des-traitements-et-de-la-persistance-therapeutique-au-cours-des-maladies-inflammatoires-chroniques-de-lintestin-mici-en-vie-reelle-dans-les-centres-hospitaliers-gene","status":"publish","type":"post","link":"https:\/\/angh.net\/abstracts\/etude-du-positionnement-des-traitements-et-de-la-persistance-therapeutique-au-cours-des-maladies-inflammatoires-chroniques-de-lintestin-mici-en-vie-reelle-dans-les-centres-hospitaliers-gene\/","title":{"rendered":"Etude du positionnement des traitements et de la persistance th\u00e9rapeutique au cours des maladies inflammatoires chroniques de l\u2019intestin (MICI) en vie r\u00e9elle dans les centres hospitaliers g\u00e9n\u00e9raux: \u00e9tude PERSIST\u2019ANGH"},"content":{"rendered":"

2025<\/b><\/p>\n

St\u00e9phane Nahon, Thierry Paupard, Fr\u00e9d\u00e9ric Heluwaert, Mathias Vidon, Armand Garioud, Antoine Blain<\/em>

Gastroent\u00e9rologie <\/b> – 27\/04\/2025 – Communication orale<\/p>\n

But de l’\u00e9tude
\nAu cours des MICI, le choix de la premi\u00e8re ligne de bioth\u00e9rapie (ou d\u2019un nouveau m\u00e9dicament) mais aussi des lignes suivantes, est un sujet largement d\u00e9battu. \u00c0 ce jour, il n\u2019y a pas ou peu de facteurs pr\u00e9dictifs d\u2019efficacit\u00e9 ou de tol\u00e9rance d\u2019une ligne de traitement par rapport \u00e0 une autre, dans la chronologie des prescriptions.<\/p>\n

M\u00e9thodologie
\nD\u00e9crire les diff\u00e9rentes s\u00e9quences th\u00e9rapeutiques \u00e0 partir de l\u2019initiation de la 1\u00e8re bioth\u00e9rapie pour le traitement de la rectocolite h\u00e9morragique (RCH) et de la maladie de Crohn (MC) au cours du temps et dans la vie r\u00e9elle.
\nCrit\u00e8re d\u2019\u00e9valuation principal :
\nLes diff\u00e9rentes s\u00e9quences th\u00e9rapeutiques seront d\u00e9crites en fonction des donn\u00e9es suivantes :
\n1.\tDur\u00e9e (persistance) de chaque traitement en fonction de la s\u00e9quence choisie.
\n2.\tRaison(s) de la modification de chaque ligne th\u00e9rapeutique (\u00e9chec primaire, secondaire, effets secondaires, choix du patient).
\n3.\tRaison(s) du choix de chaque bioth\u00e9rapie (ou d\u2019un nouveau m\u00e9dicament).
\n4.\tVoie d\u2019utilisation de l\u2019infliximab (IFX) ou du v\u00e9dolizumab (VZV) IV vs SC et de l\u2019IFX\/VZV \u00ab switch back \u00bb IV\/SC.
\nCes descriptions pourront \u00eatre stratifi\u00e9es selon la pathologie concern\u00e9e : MC ou RCH.<\/p>\n

R\u00e9sultats
\nEn date du 27 avril 2025, 917 patients atteints d’une MICI et recevant ou ayant re\u00e7u au moins une th\u00e9rapie avanc\u00e9e, ont \u00e9t\u00e9 inclus par 13 centres. Neuf centres sont en cours de signature de convention avec le CRC d’Annecy
\nUne analyse descriptive sera r\u00e9alis\u00e9e fin juillet 2025 avec pour objectif la pr\u00e9sentation des r\u00e9sultats lors du congr\u00e8s de Perpignan<\/p>\n

Conclusion
\nLes r\u00e9sultats pr\u00e9liminaires de la cohorte PERSIST’ANGH seront pr\u00e9sent\u00e9s lors du congr\u00e8s de Perpignan<\/p>\n","protected":false},"excerpt":{"rendered":"

2025 St\u00e9phane Nahon, Thierry Paupard, Fr\u00e9d\u00e9ric Heluwaert, Mathias Vidon, Armand Garioud, Antoine Blain Gastroent\u00e9rologie – 27\/04\/2025 – Communication orale But de l’\u00e9tude Au cours des MICI, le choix de la premi\u00e8re ligne de bioth\u00e9rapie (ou d\u2019un nouveau m\u00e9dicament) mais aussi des lignes suivantes, est un sujet largement d\u00e9battu. \u00c0 ce jour, il n\u2019y a pas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[49],"class_list":["post-2680","post","type-post","status-publish","format-standard","hentry","category-gastroenterologie","tag-49"],"yoast_head":"\nEtude du positionnement des traitements et de la persistance th\u00e9rapeutique au cours des maladies inflammatoires chroniques de l\u2019intestin (MICI) en vie r\u00e9elle dans les centres hospitaliers g\u00e9n\u00e9raux: \u00e9tude PERSIST\u2019ANGH - 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